HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF IOBITRIDOL IN PLASMA, URINE AND BILE

被引：5

作者：

BOURRINET, P

FELDMAN, H

DENCAUSSE, A

CHAMBON, C

BONNEMAIN, B

机构：

[1] Laboratoire Guerbet, cedex, B.P. 50400

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 670卷 / 02期

关键词：

D O I：

10.1016/0378-4347(95)00167-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Iobitridol is a new non-ionic, low-osmolality contrast medium for urography and angiography. We have developed a method for determining iobitridol in body fluids using high-performance liquid chromatography with ultraviolet detection. The method, which is specific and reproducible, does not require an internal standard. Determinations can be carried out in body fluids against a set of standards in ethanol. The method was validated for the quantification of iobitridol in biological samples obtained during pharmacokinetic studies.

引用

页码：369 / 372

页数：4

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