DISTINCT MORPHOLOGICAL AND MITO-INHIBITORY EFFECTS INDUCED BY TGF-BETA-1, HGF AND EGF ON MOUSE, RAT AND HUMAN HEPATOCYTES

被引：20

作者：

PETERSEN, B ^{[1
]}

YEE, CJ ^{[1
]}

BOWEN, W ^{[1
]}

ZARNEGAR, R ^{[1
]}

MICHALOPOULOS, GK ^{[1
]}

机构：

[1] UNIV PITTSBURGH, SCH MED, DEPT PATHOL, PITTSBURGH, PA 15261 USA

来源：

CELL BIOLOGY AND TOXICOLOGY | 1994年 / 10卷 / 04期

关键词：

ARBORESCENT CYTOPLASMIC PROCESSES; DNA SYNTHESIS;

D O I：

10.1007/BF00756762

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta 1 is known as a potent inhibitor of proliferation of rat and human hepatocytes. In this study we show that the effects of TGF-beta 1 are quite different on mouse hepatocytes. In rat and human hepatocytes, TGF-beta 1 inhibited DNA synthesis and also inhibited the morphological changes induced by growth factors in rat and human hepatocytes. In contrast, addition of TGF-beta 1 to mouse hepatocytes resulted in pronounced alterations in morphology of these cells. These changes were similar to those induced by HGF and EGF. The induction of structural changes by TGF-beta 1 was noted only in mouse hepatocytes. Mouse hepatocytes were also much more resistant to the mite-inhibitory effect of TGF-beta 1. These findings suggest profound differences in hepatocyte growth regulation between these species and may relate to observed differences in susceptibility to carcinogenesis.

引用

页码：219 / 230

页数：12