ABSENCE OF CHANGE IN HEPATIC LACTATE METABOLISM AFTER BURN INJURY

被引：2

作者：

CARTER, EA

KHALID, MA

BURKE, JF

TOMPKINS, RG

机构：

[1] Childrens, Massachusetts General Hospital, Boston

[2] Surgical Services, Massachusetts General Hospital, Boston

[3] Pediatric Gastrointestinal Unit, Massachusetts General Hospital, Boston

[4] Department of Pediatrics, Harvard Medical School, Boston

[5] Department of Surgery, Harvard Medical School, Boston

[6] Shriners Burns Institute, Boston, MA

来源：

BURNS | 1993年 / 19卷 / 06期

关键词：

D O I：

10.1016/0305-4179(93)90002-P

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In response to severe injury extraordinary quantities of lactate that are released from the peripheral tissues serve as substrate for hepatic gluconeogenesis. If is possible that as a result of burn injury, reaction kinetics involving lactate could be directly changed within the liver The metabolic fate of [U-C-14]lactate was examined in vitro in fresh liver slices after a 20 per cent total body surface area injury. Glucose and CO2 were produced in vitro by the liver tissues after the injury and no differences were seen in the metabolism of these substrates between the injured and control animals. These findings suggest that the intrinsic enzymatic processes within the liver are not directly altered by injury itself or by any of the associated inflammatory mediators which appear early after burns.

引用

页码：475 / 478

页数：4

共 21 条

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