ABSENCE OF CHANGE IN HEPATIC LACTATE METABOLISM AFTER BURN INJURY

被引：2

作者：

CARTER, EA

KHALID, MA

BURKE, JF

TOMPKINS, RG

机构：

[1] Childrens, Massachusetts General Hospital, Boston

[2] Surgical Services, Massachusetts General Hospital, Boston

[3] Pediatric Gastrointestinal Unit, Massachusetts General Hospital, Boston

[4] Department of Pediatrics, Harvard Medical School, Boston

[5] Department of Surgery, Harvard Medical School, Boston

[6] Shriners Burns Institute, Boston, MA

来源：

BURNS | 1993年 / 19卷 / 06期

关键词：

D O I：

10.1016/0305-4179(93)90002-P

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In response to severe injury extraordinary quantities of lactate that are released from the peripheral tissues serve as substrate for hepatic gluconeogenesis. If is possible that as a result of burn injury, reaction kinetics involving lactate could be directly changed within the liver The metabolic fate of [U-C-14]lactate was examined in vitro in fresh liver slices after a 20 per cent total body surface area injury. Glucose and CO2 were produced in vitro by the liver tissues after the injury and no differences were seen in the metabolism of these substrates between the injured and control animals. These findings suggest that the intrinsic enzymatic processes within the liver are not directly altered by injury itself or by any of the associated inflammatory mediators which appear early after burns.

引用

页码：475 / 478

页数：4

共 21 条

[11]

Patel, Olson, Regulation of gluconeogenesis from pyruvate and lactate in isolated perfused rat liver, Biochem. Biophys. Acta, 888, (1986)

[12]

Powis, Mullen, Wilke, Human and dog, but not rat, isolated hepatocytes have decreased foreign compound metabolizing activity compared to liver slices, Drug Metab. Dispos., 17, (1989)

[13]

Rappaport, Physioanatomic considerations, Diseases of the Liver, pp. 1-46, (1987)

[14]

Schuaffonati, Rappocciolo, Tacchini, Et al., Mechanisms of regulation of ferritin synthesis in rat liver during experimental inflammation, Experimental and Molecular Pathology, 48, (1988)

[15]

Spitzer, Bagby, Meszaros, Et al., Altered control of carbohydrate metabolism in endotoxemia, Prog. Clin. Biol. Res., 308, (1989)

[16]

Spitzer, Bagby, Hargrove, Et al., Alterations in the metabolic control of carbohydrates in sepsis, Prog. Clin. Biol. Res., 308, (1989)

[17]

Staddie, Riggs, Microtome for the preparation of tissue slices for metabolic studies of surviving tissues in vitro, J. Biol. Chem., 154, (1944)

[18]

Vary, Increased pyruvate dehydrogenase kinase activity in response to sepsis, Am. J. Physiol., 260, (1991)

[19]

Wolfe, Burke, Effect of burn trauma on glucose turnover, oxidation, and recycling in guinea pigs, Am. J. Physiol., 233, (1977)

[20]

Wolfe, Durkot, Allsop, Et al., Glucose metabolism in severely burned patients, Metabolism, 28, (1979)

← 1 2 3 →