GAINING CONTROL OVER MOLECULAR THREADING - BENEFITS OF 2ND COORDINATION SITES AND AQUEOUS-ORGANIC INTERFACES IN ROTAXANE SYNTHESIS

Rotaxane synthesis is facilitated by the presence of two functional groups on the axle reagent; the yield of rotaxane is also substantially improved by reaction in a mixed aqueous-organic phase, compared to a homogeneous phase; the benefit may be associated with reaction at the interface.