DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：58

作者：

LEMOING, JP

EDOUARD, S

LEVRON, JC

机构：

[1] Janssen Research Foundation, Laboratoires Janssen

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 614卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80327-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multi-step liquid-liquid extraction with an internal standard. The parent drug and its metabolite were separated on a cyano column used in the reversed-phase model. The coulometric detection allows quantification in the range 2-100 ng/ml. The precision, accuracy and specificity have been checked, and show that the method is reliable for clinical studies.

引用

页码：333 / 339

页数：7

共 8 条

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