PROTECTIVE EFFECT OF HETEROLOGOUS GRAM-POSITIVE VACCINE AGAINST LETHAL UPPER RESPIRATORY-TRACT INFECTION WITH TYPE-M50 GROUP-A STREPTOCOCCI IN MICE

被引：5

作者：

STJERNQUISTDESATNIK, A ^{[1
]}

KURL, DN ^{[1
]}

SCHALEN, C ^{[1
]}

CHRISTENSEN, P ^{[1
]}

机构：

[1] UNIV LUND HOSP,DEPT MED MICROBIOL,S-22185 LUND,SWEDEN

来源：

VACCINE | 1990年 / 8卷 / 02期

关键词：

local immunity; mice; Streptococci; vaccination;

D O I：

10.1016/0264-410X(90)90138-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type M50 group A streptococci are exceptional for their virulence in mice. However, intranasal (i.n.) vaccination with heat-killed group A streptococci, either of type M50 or M55, or an M12 strain deficient in M-protein, protected mice against i.n. challenge with M50 streptococci (82, 88 and 83% survival, respectively). Significant resistance against M50 streptococci was also noted by i.n. application of heat-killed Lactobacillus fermenti (81% survival) as well as two strains of pneumococci (50 and 79% survival). In contrast, no protective effect was obtained using heat-killed trypsin-treated M55 streptococci. Nor did vaccination with Escherichia coli and Pseudomonas aeruginosa induce protection against type M50. Thus, M protein was not required for immunity against type M50. The results call for a revision of the hitherto accepted view that M proteins are the only candidates for mucosal vaccines against group A streptococci. © 1990.

引用

页码：150 / 152

页数：3

共 23 条

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