INSULIN-DEPENDENT STIMULATION OF PROTEIN-SYNTHESIS BY PHOSPHORYLATION OF A REGULATOR OF 5'-CAP FUNCTION

被引：1051

作者：

PAUSE, A

BELSHAM, GJ

GINGRAS, AC

DONZE, O

LIN, TA

LAWRENCE, JC

SONENBERG, N

机构：

[1] MCGILL UNIV,DEPT BIOCHEM,MONTREAL H3G 1Y6,PQ,CANADA

[2] MCGILL UNIV,MCGILL CANC CTR,MONTREAL H3G 1Y6,PQ,CANADA

[3] BBSRC,INST ANIM HLTH,WOKING GU24 0NF,SURREY,ENGLAND

[4] WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL,ST LOUIS,MO 63110

来源：

NATURE | 1994年 / 371卷 / 6500期

关键词：

D O I：

10.1038/371762a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

引用

页码：762 / 767

页数：6

共 31 条

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