LONGITUDINAL-STUDY OF THE CELLULAR-RESPONSE TO PF155 RESA AND CIRCUMSPOROZOITE PROTEIN IN MADAGASCAR

被引：13

作者：

CHOUGNET, C

DELORON, P

LEPERS, JP

RASON, MD

SAVEL, J

COULANGES, P

机构：

[1] UNIV PARIS 05, BIOL PARASITAIRE LAB, F-75270 PARIS 06, FRANCE

[2] INST PASTEUR MADAGASCAR, ANTANANARIVO, MADAGASCAR

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

关键词：

Cellular response; Circumsporozoite protein; Pf155/RESA; Plasmodium falciparum;

D O I：

10.1016/0165-2478(90)90120-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a community follow-up conducted in the Central Highlands of Madagascar, the cellular responses to synthetic peptides from the immunodominant regions of Pf155/RESA and the repeat region of the circumsporozoite protein were studied. Seasonal variations of the T cell response were measured at the individual level; the relationship between this response and the presence of parasites in blood was assessed; the question of the possible protective value of the lymphocyte proliferation in presence of a specific antigen was addressed. © 1990.

引用

收藏

页码：231 / 236

页数：6

相关论文

共 19 条

[1] RABBIT AND HUMAN-ANTIBODIES TO A REPEATED AMINO-ACID-SEQUENCE OF PLASMODIUM-FALCIPARUM ANTIGEN, PF-155, REACT WITH THE NATIVE PROTEIN AND INHIBIT MEROZOITE INVASION [J].

BERZINS, K ;

PERLMANN, H ;

WAHLIN, B ;

CARLSSON, J ;

WAHLGREN, M ;

UDOMSANGPETCH, R ;

BJORKMAN, A ;

PATARROYO, ME ;

PERLMANN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :1065-1069

[2] IMMUNE SERA RECOGNIZE ON ERYTHROCYTES A PLASMODIUM-FALCIPARUM ANTIGEN COMPOSED OF REPEATED AMINO-ACID-SEQUENCES [J].

COPPEL, RL ;

COWMAN, AF ;

ANDERS, RF ;

BIANCO, AE ;

SAINT, RB ;

LINGELBACH, KR ;

KEMP, DJ ;

BROWN, GV .

NATURE, 1984, 310 (5980) :789-792

[3]

Cowman A F, 1984, Mol Biol Med, V2, P207

[4] EVOLUTION OF THE LEVELS OF SOLUBLE INTERLEUKIN-2 RECEPTORS DURING PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX MALARIA [J].

DELORON, P ;

LEPERS, JP ;

COULANGES, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (08) :1887-1889

[5] EFFICACY OF A 3-DAY ORAL REGIMEN OF A QUININE-QUINIDINE-CINCHONINE ASSOCIATION (QUINIMAX) FOR TREATMENT OF FALCIPARUM-MALARIA IN MADAGASCAR [J].

DELORON, P ;

LEPERS, JP ;

VERDIER, F ;

CHOUGNET, C ;

REMANAMIRIJA, JA ;

ANDRIAMANGATIANARASON, MD ;

COULANGES, P ;

JAUREGUIBERRY, G .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1989, 83 (06) :751-754

[6]

HO M, 1988, J IMMUNOL, V141, P2755

[7] ANTIGEN-SPECIFIC IMMUNOSUPPRESSION IN HUMAN MALARIA DUE TO PLASMODIUM-FALCIPARUM [J].

HO, M ;

WEBSTER, HK ;

LOOAREESUWAN, S ;

SUPANARANOND, W ;

PHILLIPS, RE ;

CHANTHAVANICH, P ;

WARRELL, DA .

JOURNAL OF INFECTIOUS DISEASES, 1986, 153 (04) :763-771

[8] T-CELL EPITOPES IN PF155 RESA, A MAJOR CANDIDATE FOR A PLASMODIUM-FALCIPARUM MALARIA VACCINE [J].

KABILAN, L ;

TROYEBLOMBERG, M ;

PERLMANN, H ;

ANDERSSON, G ;

HOGH, B ;

PETERSEN, E ;

BJORKMAN, A ;

PERLMANN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5659-5663

[9]

LEPERS JP, 1988, LANCET, V1, P586

[10] CIRCUMSPOROZOITE PROTEINS OF MALARIA PARASITES [J].

NUSSENZWEIG, V ;

NUSSENZWEIG, RS .

CELL, 1985, 42 (02) :401-403