RETRO-INVERSO AMIDE BONDS BETWEEN TRIFUNCTIONAL AMINO-ACIDS

被引：17

作者：

DURR, H

GOODMAN, M

JUNG, G

机构：

[1] UNIV TUBINGEN, INST ORGAN CHEM, MORGENSTELLE 18, W-7400 TUBINGEN 1, GERMANY

[2] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1992年 / 31卷 / 06期

关键词：

D O I：

10.1002/anie.199207851

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a highly functionalized nonapeptide the amide linkage -CONH- between glutamine and arginine was inverted to -NHCO-. As an example of this difficult modification of the peptide backbone, a retro-inverso killer-cell epitope was synthesized for the first time with a combination of solution and solid-phase peptide synthesis techniques. The synthetic methods used are of importance for the rational design and drugs based on peptides.

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页码：785 / 787

页数：3

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