ALTERNATIVE PATHWAYS OF SULFITE OXIDATION IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES

被引:10
作者
CONSTANTIN, D
MEHROTRA, K
JERNSTROM, B
TOMASI, A
MOLDEUS, P
机构
[1] KAROLINSKA INST,INST ENVIRONM MED,DIV TOXICOL,S-17177 STOCKHOLM,SWEDEN
[2] UNIV MODENA,DEPT GEN PATHOL,MODENA,ITALY
来源
PHARMACOLOGY & TOXICOLOGY | 1994年 / 74卷 / 02期
关键词
D O I
10.1111/j.1600-0773.1994.tb01088.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sodium sulfite is metabolized by human polymorphonuclear leukocytes by two alternative pathways, one enzymatic route dependent on sulfite oxidase and one non-enzymatic which involves intermediate formation of sulfur trioxide anion radicals. Initiation of the oxidative burst by phorbol myristate acetate significantly stimulates sulfate formation through the second pathway. The activity of sulfite oxidase in polymorphonuclear leukocytes varies greatly among individuals, a variation consistent with the suggested polymorphic distribution of sulfite oxidase in the human population.
引用
收藏
页码:136 / 140
页数:5
相关论文
共 26 条
[1]   THE SUPEROXIDE-FORMING ENZYMATIC SYSTEM OF PHAGOCYTES [J].
BELLAVITE, P .
FREE RADICAL BIOLOGY AND MEDICINE, 1988, 4 (04) :225-261
[2]   OCCURRENCE AND COMPARISON OF SULFITE OXIDASE ACTIVITY IN MAMMALIAN-TISSUES [J].
CABRE, F ;
MARIN, C ;
CASCANTE, M ;
CANELA, EI .
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1990, 43 (02) :159-162
[3]   SODIUM NITRITE-STIMULATED METABOLIC-ACTIVATION OF BENZO[A]PYRENE 7,8-DIHYDRODIOL IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].
CONSTANTIN, D ;
JERNSTROM, B ;
COTGREAVE, IA ;
MOLDEUS, P .
CARCINOGENESIS, 1991, 12 (05) :777-781
[4]   BIOCHEMISTRY OF SULFUR-CONTAINING AMINO-ACIDS [J].
COOPER, AJL .
ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :187-222
[5]   METHODOLOGIES FOR THE APPLICATION OF MONOBROMOBIMANE TO THE SIMULTANEOUS ANALYSIS OF SOLUBLE AND PROTEIN THIOL COMPONENTS OF BIOLOGICAL-SYSTEMS [J].
COTGREAVE, IA ;
MOLDEUS, P .
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1986, 13 (4-5) :231-249
[6]   GASTROINTESTINAL METABOLISM OF N-ACETYLCYSTEINE IN THE RAT, INCLUDING AN ASSAY FOR SULFITE IN BIOLOGICAL-SYSTEMS [J].
COTGREAVE, IA ;
BERGGREN, M ;
JONES, TW ;
DAWSON, J ;
MOLDEUS, P .
BIOPHARMACEUTICS & DRUG DISPOSITION, 1987, 8 (04) :377-386
[7]   PEROXIDASE-CATALYZED OXIDATION OF (BI)SULFITE - REACTION OF FREE-RADICAL METABOLITES OF (BI)SULFITE WITH (+/-)-7,8-DIHYDROXY-7,8-DI-HYDROBENZO[A]PYRENE [J].
CURTIS, JF ;
HUGHES, MF ;
MASON, RP ;
ELING, TE .
CARCINOGENESIS, 1988, 9 (11) :2015-2021
[8]  
FRIDOVICH I, 1961, J BIOL CHEM, V236, P1836
[9]   THE RATE OF OXYGEN-CONSUMPTION AND SUPEROXIDE ANION FORMATION BY STIMULATED HUMAN-NEUTROPHILS - THE EFFECT OF PARTICLE CONCENTRATION AND SIZE [J].
GREEN, MJ ;
HILL, HAO ;
TEW, DG .
FEBS LETTERS, 1987, 216 (01) :31-34
[10]   SULFITE TOXICITY - A CRITICAL-REVIEW OF INVITRO AND INVIVO DATA [J].
GUNNISON, AF .
FOOD AND COSMETICS TOXICOLOGY, 1981, 19 (05) :667-682