ALTERNATIVE PATHWAYS OF SULFITE OXIDATION IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES

被引：10

作者：

CONSTANTIN, D

MEHROTRA, K

JERNSTROM, B

TOMASI, A

MOLDEUS, P

机构：

[1] KAROLINSKA INST,INST ENVIRONM MED,DIV TOXICOL,S-17177 STOCKHOLM,SWEDEN

[2] UNIV MODENA,DEPT GEN PATHOL,MODENA,ITALY

来源：

PHARMACOLOGY & TOXICOLOGY | 1994年 / 74卷 / 02期

关键词：

D O I：

10.1111/j.1600-0773.1994.tb01088.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sodium sulfite is metabolized by human polymorphonuclear leukocytes by two alternative pathways, one enzymatic route dependent on sulfite oxidase and one non-enzymatic which involves intermediate formation of sulfur trioxide anion radicals. Initiation of the oxidative burst by phorbol myristate acetate significantly stimulates sulfate formation through the second pathway. The activity of sulfite oxidase in polymorphonuclear leukocytes varies greatly among individuals, a variation consistent with the suggested polymorphic distribution of sulfite oxidase in the human population.

引用

页码：136 / 140

页数：5

共 26 条

[21] EPOXIDATION OF (+/-)-7,8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE DURING (BI)SULFITE AUTOXIDATION - ACTIVATION OF A PROCARCINOGEN BY A COCARCINOGEN [J].