DISTRIBUTION AND METABOLISM OF POLYCYCLIC AROMATIC-HYDROCARBONS (PAHS) INJECTED INTO EGGS OF CHICKEN (GALLUS-DOMESTICUS) AND COMMON EIDER DUCK (SOMATERIA-MOLLISSIMA)

被引:66
作者
NAF, C [1 ]
BROMAN, D [1 ]
BRUNSTROM, B [1 ]
机构
[1] UNIV UPPSALA, DEPT ZOOPHYSIOL, S-75122 UPPSALA, SWEDEN
关键词
POLYCYCLIC AROMATIC HYDROCARBONS; SOMATERIA-MOLLISSIMA; GALLUS-DOMESTICUS; METABOLISM;
D O I
10.1002/etc.5620111114
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The present study focuses on the uptake, distribution, and metabolism of 16 polycyclic aromatic hydrocarbons (PAHs) injected into eggs of chicken (Gallus domesticus) and common eider (Somateria mollissima). Of the total dose of 0.2 ppm, injected on day 4 of incubation, 94% was metabolized within the chicken egg by day 18. The gallbladder showed the highest PAH concentrations of the analyzed organs/structures (gallbladder, liver, kidney, adipose tissue) of the chick and eider embryos. The proportion of the total PAH content present in these organs/structures was higher in the eider embryo (40%) than in the chick embryo (16%). Chick embryos, eider embryos, and wild juvenile eiders had similar PAH concentrations and PAH profiles. The characteristics of this "PAH pool" seemed to be largely unrelated to the relative concentrations of the PAHs to which the birds were exposed, the age of the organisms, and the routes of exposure. The largest studied PAH molecule, coronene, was not taken up from the yolk by the embryo as efficiently as the other PAHs, but once taken up it was metabolized as readily as the others. Basal aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH) activities of chick and eider embryos were of similar magnitude.
引用
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页码:1653 / 1660
页数:8
相关论文
共 24 条
[21]  
NEBERT DW, 1968, J BIOL CHEM, V243, P6242
[22]   PREDICTION OF PARTITION-COEFFICIENTS OF UNSUBSTITUTED POLYCYCLIC AROMATIC-HYDROCARBONS FROM C-18 CHROMATOGRAPHIC AND STRUCTURAL-PROPERTIES [J].
RUEPERT, C ;
GRINWIS, A ;
GOVERS, H .
CHEMOSPHERE, 1985, 14 (3-4) :279-291
[23]   BIOTRANSFORMATION, BIOACCUMULATION AND LETHALITY OF 2,8-DICHLORODIBENZO-P-DIOXIN - A PROPOSAL TO EXPLAIN THE BIOTIC FATE AND TOXICITY OF PCDDS AND PCDFS [J].
SIJM, DTHM ;
OPPERHUIZEN, A .
CHEMOSPHERE, 1988, 17 (01) :83-99
[24]   HEPATIC-MICROSOMAL MONOOXYGENASES OF SEA BIRDS [J].
WALKER, CH ;
KNIGHT, GC ;
CHIPMAN, JK ;
RONIS, MJJ .
MARINE ENVIRONMENTAL RESEARCH, 1984, 14 (1-4) :416-419