TRANSCRIPTIONAL REGULATORY ELEMENTS DOWNSTREAM OF THE JUNB GENE

被引：54

作者：

PEREZALBUERNE, ED ^{[1
]}

SCHATTEMAN, G ^{[1
]}

SANDERS, LK ^{[1
]}

NATHANS, D ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GEN,BALTIMORE,MD 21205

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 24期

关键词：

GENE ACTIVATION; GROWTH FACTORS; SERUM RESPONSE ELEMENT;

D O I：

10.1073/pnas.90.24.11960

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

JunB is an immediate early transcription factor that is induced by a variety of extracellular signaling agents, including growth factors, phorbol esters, and agents that elevate cyclic AMP. The mechanism of activation of the gene encoding JunB by these agents is not well understood. By using the JunB gene together with flanking DNA in transfection experiments, we show that a serum response element (SRE) and/or a cAMP response element (CRE) downstream of the gene mediate the response of the gene in mouse NIH 3T3 cells to serum, platelet-derived growth factor, basic fibroblast growth factor, phorbol ester, and forskolin. In addition, a segment of DNA just upstream of the TATA box is required for optimal activation of the gene.

引用

页码：11960 / 11964

页数：5

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