THE PHARMACOLOGY OF VESAMICOL - AN INHIBITOR OF THE VESICULAR ACETYLCHOLINE TRANSPORTER

被引：49

作者：

PRIOR, C ^{[1
]}

MARSHALL, IG ^{[1
]}

PARSONS, SM ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA,DEPT CHEM,SANTA BARBARA,CA 93016

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0306-3623(92)90280-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Vesamicol (2-[4-phenylpiperidino] cyclohexanol) inhibits the transport of acetylcholine into synaptic vesicles in cholinergic nerve terminals. 2. Recent pharmacological studies of the effects of vesamicol on skeletal neuromuscular transmission have revealed a pattern of activity for the compound consistent with the neurochemical observation of the mechanism of action of the compound. 3. Pharmacological manipulation of vesicular acetylcholine transport has been used to investigate the recycling and mobilization of synaptic vesicles within cholinergic nerve terminals. 4. In addition to its effects on vesicular acetylcholine transport, vesamicol also possesses some sodium channel and alpha-adrenoceptor blocking activity. 5. Vesamicol clearly represents a unique tool for investigating presynaptic mechanisms in cholinergic nerve terminals.

引用

页码：1017 / 1022

页数：6

共 40 条

[31] ACETYLCHOLINE RECYCLING AND RELEASE AT RAT MOTOR-NERVE TERMINALS STUDIED USING (-)-VESAMICOL AND TROXPYRROLIUM
SEARL, T
PRIOR, C
MARSHALL, IG
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 444 : 99 - 116
[32] THE EFFECTS OF L-VESAMICOL, AN INHIBITOR OF VESICULAR ACETYLCHOLINE UPTAKE, ON 2 POPULATIONS OF MINIATURE ENDPLATE CURRENTS AT THE SNAKE NEUROMUSCULAR-JUNCTION
SEARL, T
PRIOR, C
MARSHALL, IG
[J]. NEUROSCIENCE, 1990, 35 (01) : 145 - 156
[33] STORAGE AND RELEASE OF ACETYLCHOLINE IN RAT CORTICAL SYNAPTOSOMES - EFFECTS OF D,L-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL (AH5183)
SUSZKIW, JB
TOTH, G
[J]. BRAIN RESEARCH, 1986, 386 (1-2) : 371 - 378
[34] SUSZKIW JB, 1987, CELLULAR MOL BASIS C, P323
[35] TOLL L, 1980, J BIOL CHEM, V255, P1787
[36] 2-(4-PHENYLPIPERIDINO) CYCLOHEXANOL (AH5183) DECREASES QUANTAL SIZE AT THE FROG NEUROMUSCULAR-JUNCTION
VANDERKLOOT, W
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1986, 406 (01): : 83 - 85
[37] ALPHA-ADRENOCEPTOR BLOCKING PROPERTIES OF VESAMICOL
WANNAN, G
PRIOR, C
MARSHALL, IG
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 201 (01) : 29 - 34
[38] REDUCTION OF QUANTAL SIZE BY VESAMICOL (AH5183), AN INHIBITOR OF VESICULAR ACETYLCHOLINE STORAGE
WHITTON, PS
MARSHALL, IG
PARSONS, SM
[J]. BRAIN RESEARCH, 1986, 385 (01) : 189 - 192
[39] SEPARATION OF SYNAPTIC VESICLES OF DIFFERENT FUNCTIONAL-STATES FROM CHOLINERGIC SYNAPSES OF TORPEDO ELECTRIC ORGAN
ZIMMERMANN, H
DENSTON, CR
[J]. NEUROSCIENCE, 1977, 2 (05) : 715 - &
[40] RECYCLING OF SYNAPTIC VESICLES IN CHOLINERGIC SYNAPSES OF TORPEDO ELECTRIC ORGAN DURING INDUCED TRANSMITTER RELEASE
ZIMMERMANN, H
DENSTON, CR
[J]. NEUROSCIENCE, 1977, 2 (05) : 695 - 714

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