REACTIVE EXTRACTION OF PENICILLIN .2. DISTRIBUTION COEFFICIENTS AND DEGREES OF EXTRACTION

The equilibrium constants and degrees of extraction of penicillin G are investigated by using primary, secondary and tertiary amines as carriers and a range of pH values and concentrations of penicillins and amines for various solvents. In these ion pair extractions the extraction and re-extraction can be controlled by settling a suitable pH value. When secondary and tertiary amines are used, the extraction and re-extraction of penicillin G is possible in the pH range from 5 to 7 in which penicillin G is stable enough to use common extractors at room temperature. When quaternary amines are used, the extraction is coupled with an ion exchange process.