IMMUNOHISTOCHEMICAL LOCALIZATION OF THE ALPHA-1, ALPHA-2 AND ALPHA-3 SUBUNIT OF THE GABA-A RECEPTOR IN THE RAT-BRAIN

被引：99

作者：

ZIMPRICH, F

ZEZULA, J

SIEGHART, W

LASSMANN, H

机构：

[1] NEUROL INST,AUSTRIAN ACAD SCI,EXPTL NEUROPATHOL RES UNIT,SCHWARZSPANIERSTR 17,A-1090 VIENNA,AUSTRIA

[2] UNIV VIENNA,PSYCHIAT KLIN,DEPT BIOCHEM PSYCHIAT,A-1010 VIENNA,AUSTRIA

[3] UNIV VIENNA,INST NEUROL,A-1010 VIENNA,AUSTRIA

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

关键词：

GABA-A RECEPTOR; ALPHA-SUBUNIT; HETEROGENEITY; IMMUNOHISTOCHEMISTRY; THALAMIC RETICULAR NUCLEUS; HIPPOCAMPUS; STRIATUM; GLOBUS-PALLIDUS;

D O I：

10.1016/0304-3940(91)90910-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immunohistochemical distribution of the alpha-1, alpha-2 and alpha-3 subunit of the gamma-aminobutyric acid-A (GABA(A)) receptor was investigated in the rat brain using affinity-purified antibodies against unique parts of the amino acid sequence of the respective subunits. The distribution of the 3 subunits differed markedly from each other indicating heterogeneity of the GABA(A)-receptor composition in different brain regions and at various receptive compartments (dendrites or somata) of neuronal cells.

引用

页码：125 / 128

页数：4

共 20 条

[1] IDENTIFICATION OF ALPHA-2-SUBUNIT AND ALPHA-3-SUBUNIT OF THE GABA-A-BENZODIAZEPINE RECEPTOR COMPLEX PURIFIED FROM THE BRAINS OF YOUNG-RATS [J].