CHIRAL AUXILIARY-MEDIATED ASYMMETRIC INDUCTION IN A THERMAL INVERSE ELECTRON DEMAND HETERO-DIELS-ALDER REACTION - ENANTIOSELECTIVE SYNTHESIS OF THE TAXOL A-RING SIDE-CHAIN

被引：46

作者：

SWINDELL, CS

TAO, M

机构：

[1] Department of Chemistry, Bryn Mawr College, Pennsylvania 19010-2899, 101 North Merion Avenue, Bryn Mawr

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 22期

关键词：

D O I：

10.1021/jo00074a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral auxiliary-modified ketene acetal 5g and N-benzoylbenzaldimine (4) engage in an endo and pi-facially selective thermal inverse electron demand hetero-Diels-Alder reaction that is the key step in a synthesis of enantiomerically pure taxol A-ring side-chain methyl ester 9.

引用

页码：5889 / 5891

页数：3

共 55 条

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