THE SODIUM LAURYL SULFATE MODEL - AN OVERVIEW

被引：127

作者：

LEE, CH ^{[1
]}

MAIBACH, HI ^{[1
]}

机构：

[1] HALLYM UNIV,KANGNAM SACRED HEART HOSP,COLL MED,DEPT DERMATOL,SEOUL 150071,SOUTH KOREA

来源：

CONTACT DERMATITIS | 1995年 / 33卷 / 01期

关键词：

SODIUM LAURYL SULFATE; ANIONIC SURFACTANTS; IRRITANT CONTACT DERMATITIS; CUTANEOUS IRRITATION; BIOENGINEERING METHODS; ATOPY; SENSITIVE SKIN;

D O I：

10.1111/j.1600-0536.1995.tb00438.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Irritant contact dermatitis is a complex entity with several clinical forms (acute, cumulative, etc.) and multiple mechanisms. Sodium lauryl sulfate (SLS), the most widely utilized model for studying acute and cumulative irritation, has proved highly practical and informative for such studies. This article summarizes several decades of investigation, and provides details of dosing, application method (closed versus open), and biologic endpoints (visual grading, transepidermal water loss) that may be utilized in future studies.

引用

页码：1 / 7

页数：7

共 92 条

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[6] INDIVIDUAL AND INSTRUMENTAL VARIATIONS IN IRRITANT PATCH-TEST REACTIONS - CLINICAL-EVALUATION AND QUANTIFICATION BY BIOENGINEERING METHODS [J].

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CONTACT DERMATITIS, 1989, 21 (03) :184-188

[8] SKIN REACTIONS TO IRRITANTS ASSESSED BY NON-INVASIVE BIOENGINEERING METHODS [J].

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CONTACT DERMATITIS, 1989, 20 (05) :352-359

[9] BASAL TRANSEPIDERMAL WATER-LOSS, SKIN THICKNESS, SKIN BLOOD-FLOW AND SKIN COLOR IN RELATION TO SODIUM-LAURYL-SULFATE-INDUCED IRRITATION IN NORMAL SKIN [J].

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