COMBINED MODALITY RADIOPROTECTION - THE USE OF GLUCAN AND SELENIUM WITH WR-2721

被引:57
作者
PATCHEN, ML [1 ]
MACVITTIE, TJ [1 ]
WEISS, JF [1 ]
机构
[1] ARMED FORCES RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD 20814
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 18卷 / 05期
关键词
Drug interactions; Glucan; Hemopoiesis; Radioprotection; Selenium; WR-2721;
D O I
10.1016/0360-3016(90)90442-M
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Glucan, WR-2721, and selenium, three agents with distinct radioprotective mechanisms, were evaluated in C3H HeN mice for survival-enhancing and hemopoietic-regenerating effects when administered alone or in combinations before exposure to 60Co radiation. At LD50/30 radiation doses (radiation doses lethal for 50% of mice within 30 days postexposure), dose reduction factors of 1.21, 1.02, 1.37, 1.51, and 1.66 were obtained following glucan (75 mg/kg i.v., -20 hr), selenium (0.8 mg/kg, i.p., -20 hr), WR-2721 (200 mg/kg, i.p., -30 min), glucan + WR-2721, and glucan + selenium + WR-2721 treatments, respectively. All treatments increased numbers of hemopoietic stem cells as measured by the day 12 endogenous spleen colony-forming unit (E-CFU) assay; the most significant E-CFU effects, however, were observed following glucan + WR-2721 and glucan + selenium + WR-2721 treatments. Combined modality treatments were also more effective than single-agent treatments at accelerating bone marrow and splenic granulocyte-macrophage colony-forming cell (GM-CFC) regeneration. These results demonstrate the value of multiple-agent radioprotectants. © 1990.
引用
收藏
页码:1069 / 1075
页数:7
相关论文
共 38 条
[11]   COMPARATIVE TUMOR-INHIBITORY AND ANTI-BACTERIAL ACTIVITY OF SOLUBLE AND PARTICULATE GLUCAN [J].
DILUZIO, NR ;
WILLIAMS, DL ;
MCNAMEE, RB ;
EDWARDS, BF ;
KITAHAMA, A .
INTERNATIONAL JOURNAL OF CANCER, 1979, 24 (06) :773-779
[12]  
FINNEY DJ, 1978, STATISTICAL METHODS
[13]  
Giambarresi L, 1987, MILITARY RADIOBIOLOG, P265
[14]   STUDIES ON SUSCEPTIBILITY TO INFECTION FOLLOWING IONIZING RADIATION .1. THE TIME OF ONSET AND DURATION OF THE ENDOGENOUS BACTEREMIAS IN MICE [J].
HAMMOND, CW ;
TOMPKINS, M ;
MILLER, CP .
JOURNAL OF EXPERIMENTAL MEDICINE, 1954, 99 (05) :405-410
[15]  
JACOBS AJ, 1983, 7TH P INT C RAD RES, pD5
[16]  
KINNAMON KE, 1980, P SOC EXP BIOL MED, V164, P370
[17]   LONG-TERM EFFECTS OF RADIOPROTECTOR WR-2721 ON LOCOMOTOR-ACTIVITY AND BODY-WEIGHT OF MICE FOLLOWING EXPOSURE TO IONIZING-RADIATION [J].
LANDAUER, MR ;
DAVIS, HD ;
DOMINITZ, JA ;
WEISS, JF .
TOXICOLOGY, 1988, 49 (2-3) :315-323
[18]   POLYSACCHARIDES INDUCE RADIOPROTECTION OF MURINE HEMATOPOIETIC STEM-CELLS AND INCREASE THE LD50/30 DAYS [J].
MAISIN, JR ;
KONDITAMBA, A ;
MATTELIN, G .
RADIATION RESEARCH, 1986, 105 (02) :276-281
[19]   REDUCTION OF SHORT- AND LONG-TERM RADIATION LETHALITY BY MIXTURES OF CHEMICAL PROTECTORS [J].
MAISIN, JR ;
MATTELIN, G ;
FRIDMANM.A ;
VANDERPA.J .
RADIATION RESEARCH, 1968, 35 (01) :26-&
[20]  
NYGAARD OF, 1983, RADIOPROTECTORS ANTI