NEUROTRANSMITTER TRANSPORTERS (PLUS) - A PROMISING NEW GENE FAMILY

被引：167

作者：

UHL, GR

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21224 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21224 USA

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 07期

关键词：

D O I：

10.1016/0166-2236(92)90068-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotransmitter transporter genes encode proteins with 12 putative transmembrane regions, which mediate Na+-dependent reaccumulation of released neurotransmitters into presynaptic terminals and are the sites of action of important abused and therapeutic drugs. Studies of these genes show promise for improving our understanding of transport mechanisms and modes of drug action, and may even uncover previously unanticipated neurotransmitters.

引用

页码：265 / 268

页数：4

共 45 条

[21] STRUCTURAL AND FUNCTIONAL-STUDIES ON THE SODIUM-COUPLED AND CHLORIDE-COUPLED GAMMA-AMINOBUTYRIC ACID TRANSPORTER - DEGLYCOSYLATION AND LIMITED PROTEOLYSIS
KANNER, BI
KEYNAN, S
RADIAN, R
[J]. BIOCHEMISTRY, 1989, 28 (09) : 3722 - 3728
[22] GAMMA-AMINOBUTYRIC ACID TRANSPORT IN RECONSTITUTED PREPARATIONS FROM RAT-BRAIN - COUPLED SODIUM AND CHLORIDE FLUXES
KEYNAN, S
KANNER, BI
[J]. BIOCHEMISTRY, 1988, 27 (01) : 12 - 17
[23] KITAYAMA S, IN PRESS P NATL ACAD
[24] ISOLATION AND RECONSTITUTION OF THE HIGH-AFFINITY CHOLINE CARRIER
KNIPPER, M
BOEKHOFF, I
BREER, H
[J]. FEBS LETTERS, 1989, 245 (1-2) : 235 - 237
[25] ADENYLYL CYCLASE AMINO-ACID SEQUENCE - POSSIBLE CHANNEL-LIKE OR TRANSPORTER-LIKE STRUCTURE
KRUPINSKI, J
COUSSEN, F
BAKALYAR, HA
TANG, WJ
FEINSTEIN, PG
ORTH, K
SLAUGHTER, C
REED, RR
GILMAN, AG
[J]. SCIENCE, 1989, 244 (4912) : 1558 - 1564
[26] SYNAPTOSOMAL TRANSPORT - CHLORIDE DEPENDENCE FOR CHOLINE, GABA, GLYCINE AND SEVERAL OTHER COMPOUNDS
KUHAR, MJ
ZARBIN, MA
[J]. JOURNAL OF NEUROCHEMISTRY, 1978, 31 (01) : 251 - 256
[27] THE DOPAMINE HYPOTHESIS OF THE REINFORCING PROPERTIES OF COCAINE
KUHAR, MJ
RITZ, MC
BOJA, JW
[J]. TRENDS IN NEUROSCIENCES, 1991, 14 (07) : 299 - 302
[28] DOPAMINE TRANSPORTER - DEGLYCOSYLATION WITH EXOGLYCOSIDASES AND ENDOGLYCOSIDASES
LEW, R
GRIGORIADIS, D
WILSON, A
BOJA, JW
SIMANTOV, R
KUHAR, MJ
[J]. BRAIN RESEARCH, 1991, 539 (02) : 239 - 246
[29] MAMMALIAN AND BACTERIAL SUGAR-TRANSPORT PROTEINS ARE HOMOLOGOUS
MAIDEN, MCJ
DAVIS, EO
BALDWIN, SA
MOORE, DCM
HENDERSON, PJF
[J]. NATURE, 1987, 325 (6105) : 641 - 643
[30] EXPRESSION CLONING OF A COCAINE-SENSITIVE AND ANTIDEPRESSANT-SENSITIVE HUMAN NORADRENALINE TRANSPORTER
PACHOLCZYK, T
BLAKELY, RD
AMARA, SG
[J]. NATURE, 1991, 350 (6316) : 350 - 354

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