SYNTHESIS OF NOVEL CYCLOPROPANE NUCLEOSIDE ANALOGS

被引：16

作者：

GRANGIER, G ^{[1
]}

AITKEN, DJ ^{[1
]}

GUILLAUME, D ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] FAC SCI PHARMACEUT & BIOL PARIS,CHIM THERAPEUT LAB,CNRS,URA 1310,F-75270 PARIS,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)73353-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The short syntheses of the (+/-)-1-cyano-2-(hydroxymethyl)cyclopropyl derivatives and the related (+/-)-2,3-methanobutyrolactone-2-yl derivatives of uracil, thymine and cytosine are described. The key step is the condensation of an N-cyanomethyl-pyrimidinedione base with epibromohydrin.

引用

页码：4355 / 4356

页数：2

共 16 条

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