IN VIVO METABOLISM OF 3BETA-ACETOXYCHOL-5-ENOIC-24-14C ACID IN RAT

被引：7

作者：

NAKADA, F

OSHIO, R

SASAKI, S

YAMASAKI, H

YAMAGA, N

YAMASAKI, K

机构：

[1] Department of Biochemistry, Tottori University School of Medicine, Yonago

来源：

JOURNAL OF BIOCHEMISTRY | 1968年 / 64卷 / 04期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a128921

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3β-Acetoxychol-5-enoic-24-14C acid was administered to a rat with a bile fistula. Bile samples were collected, and the following natural and unnatural bile acids were identified as metabolites: 3α- and 3β-hydroxy-cholanoic acids of the 5β- and 5α-series; 3e{open}, 6e{open}-dihydroxycholanoic acids of the 5β- and 5α-series which were identified as 3, 6-dioxo-5β-cholanoic and 3, 6-dioxo-5α-cholanoic acids after oxidation; 3α, 7α-, 3α, 7β- and possibly 3β, 7e{open}-dihydroxy-5β-cholanoic acids. From this result a tentative pathway leading to those metabolites is presented. © 1968 by the Journal of Biochemistry.

引用

页码：495 / &

共 22 条

[1] SEPARATION OF BILE ACIDS WITH REVERSED PHASE PARTITION CHROMATOGRAPHY [J].