INCREASED BRAIN CONCENTRATIONS OF A NEUROTOXIN, 3-HYDROXYKYNURENINE, IN HUNTINGTONS-DISEASE

被引：127

作者：

PEARSON, SJ ^{[1
]}

REYNOLDS, GP ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 144卷 / 1-2期

关键词：

3-HYDROXYKYNURENINE; HUNTINGTONS DISEASE; ALZHEIMERS DISEASE; HUMAN POSTMORTEM BRAIN; TRYPTOPHAN METABOLISM; NEUROTOXIN;

D O I：

10.1016/0304-3940(92)90749-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Concentrations of the neurotoxic tryptophan metabolite, 3-hydroxykynurenine, were determined in brain tissue taken post-mortem from patients with Huntington's disease and Alzheimer's disease. 3-Hydroxykynurenine was substantially and significantly increased in all three brain areas studied in Huntington's disease, but not significantly increased in the cortex in Alzheimer's disease, when compared to matched controls. These results demonstrate a possible dysfunction of tryptophan metabolism, via the kynurenine pathway, in Huntington's disease.

引用

页码：199 / 201

页数：3

共 13 条

[1] KYNURENINE PATHWAY MEASUREMENTS IN HUNTINGTONS-DISEASE STRIATUM - EVIDENCE FOR REDUCED FORMATION OF KYNURENIC ACID [J].

BEAL, MF ;

MATSON, WR ;

SWARTZ, KJ ;

GAMACHE, PH ;

BIRD, ED .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (04) :1327-1339

[2] INCREASE IN KYNURENIC ACID IN HUNTINGTONS-DISEASE MOTOR CORTEX [J].

CONNICK, JH ;

CARLA, V ;

MORONI, F ;

STONE, TW .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (03) :985-987

[3] CYTO-TOXICITY OF 3-HYDROXYKYNURENINE IN A NEURONAL HYBRID CELL-LINE [J].

EASTMAN, CL ;

GUILARTE, TR .

BRAIN RESEARCH, 1989, 495 (02) :225-231

[4] INCREASED CONCENTRATIONS OF 3-HYDROXYKYNURENINE IN VITAMIN-B6 DEFICIENT NEONATAL RAT-BRAIN [J].

GUILARTE, TR ;

WAGNER, HN .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (06) :1918-1926

[5] SYSTEMIC ENDOTOXIN INCREASES L-TRYPTOPHAN, 5-HYDROXYINDOLEACETIC ACID, 3-HYDROXYKYNURENINE AND QUINOLINIC ACID CONTENT OF MOUSE CEREBRAL-CORTEX [J].

HEYES, MP ;

QUEARRY, BJ ;

MARKEY, SP .

BRAIN RESEARCH, 1989, 491 (01) :173-179

[6] KYNURENINES AND SEIZURES [J].

LAPIN, IP .

EPILEPSIA, 1981, 22 (03) :257-265

[7] DETERMINATION OF 3-HYDROXYKYNURENINE IN HUMAN BRAIN AND PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION - INCREASED CONCENTRATIONS IN HEPATIC-ENCEPHALOPATHY [J].

PEARSON, SJ ;

REYNOLDS, GP .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 565 (1-2) :436-440

[8] BRAIN QUINOLINIC ACID IN HUNTINGTONS-DISEASE [J].

REYNOLDS, GP ;

PEARSON, SJ ;

HALKET, J ;

SANDLER, M .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1959-1960

[9]

REYNOLDS GP, 1989, LANCET, V2, P979

[10] QUINOLINIC ACID - AN ENDOGENOUS METABOLITE THAT PRODUCES AXON-SPARING LESIONS IN RAT-BRAIN [J].

SCHWARCZ, R ;

WHETSELL, WO ;

MANGANO, RM .

SCIENCE, 1983, 219 (4582) :316-318

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