THE HUMAN BRAIN RESONANCE OF CHOLINE-CONTAINING COMPOUNDS IS SIMILAR IN PATIENTS RECEIVING LITHIUM TREATMENT AND CONTROLS - AN INVIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDY

被引：32

作者：

STOLL, AL

RENSHAW, PF

SACHS, GS

GUIMARAES, AR

MILLER, C

COHEN, BM

LAFER, B

GONZALEZ, RG

机构：

[1] HARVARD UNIV,SCH MED,HARVARD BIPOLAR RES GRP,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,CONSOLIDATED DEPT PSYCHIAT,BOSTON,MA 02115

[3] MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,BOSTON,MA 02114

[4] MASSACHUSETTS GEN HOSP,MCLEAN BIPOLAR RES GRP,BOSTON,MA 02114

[5] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,CTR NMR,BOSTON,MA 02114

[6] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,DIV NEURORADIOL,BOSTON,MA 02114

[7] MIT,DEPT NUCL ENGN,RADIOL SCI PROGRAM,CAMBRIDGE,MA 02139

来源：

BIOLOGICAL PSYCHIATRY | 1992年 / 32卷 / 10期

关键词：

D O I：

10.1016/0006-3223(92)90184-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lithium specifically and potentially inhibits membrane transport of choline. However, the effect of lithium on human neuronal choline content is unknown. This study was performed to determine if lithium alters the human brain choline concentration in vivo. In vivo proton magnetic resonance spectroscopy was used to compare the relative brain concentration of choline-containing compounds in seven lithium-treated patients and six lithium-free controls. No significant difference was observed in the mean relative choline resonance between the patient and control groups. Lithium treatment did not appear to alter the overall brain content of choline-containing compounds. It remains possible that a component of these compounds, particularly free choline, is elevated during lithium treatment.

引用

页码：944 / 949

页数：6

共 22 条

[1] LEVELS OF PHOSPHOLIPID CATABOLIC INTERMEDIATES, GLYCEROPHOSPHOCHOLINE AND GLYCEROPHOSPHOETHANOLAMINE, ARE ELEVATED IN BRAINS OF ALZHEIMERS-DISEASE BUT NOT OF DOWNS-SYNDROME PATIENTS [J].