CYTOKINE GENE-EXPRESSION IN MICE AT AN EARLY-STAGE OF INFECTION WITH VARIOUS STRAINS OF LISTERIA SPP DIFFERING IN VIRULENCE

被引：43

作者：

XIONG, HB ^{[1
]}

KAWAMURA, I ^{[1
]}

NISHIBORI, T ^{[1
]}

MITSUYAMA, M ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT BACTERIOL,NIIGATA 951,JAPAN

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 09期

关键词：

D O I：

10.1128/IAI.62.9.3649-3654.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By using reverse transcription-PCR, cytokine gene expression was examined in mice 24 h after infection with various strains of Listeria spp. differing in virulence as determined by in vivo growth and 50% lethal dose values. All the virulent strains of Listeria monocytogenes induced the expression of mRNAs specific for interleukin-1 alpha (IL-1 alpha), gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) in the spleen of mice, while an L. monocytogenes strain incapable of producing listeriolysin 0 and strains of Listeria innocua induced the expression of TNF-alpha mRNA only. The levels of expression of IL-1 alpha and IFN-gamma mRNAs were proportional to the levels of listeriolysin 0 produced by each strain. Those strains which induced the expression of IFN-gamma were capable of generating protective immunity in the infected host, suggesting that the virulence-related induction of some cytokine at the initial stage of infection plays a role in the induction of acquired cellular resistance to L. monocytogenes.

引用

页码：3649 / 3654

页数：6

共 38 条

[21] PLEIOTROPIC CONTROL OF LISTERIA-MONOCYTOGENES VIRULENCE FACTORS BY A GENE THAT IS AUTOREGULATED [J].