CRYSTAL-STRUCTURES OF 5-ALPHA,6-ALPHA,-EPOXY AND 2,3-DIHYDRO DERIVATIVES OF PHYSALIN-B, A 13,14-SECO-16,24-CYCLOSTEROID, AND THEIR H-1-NMR SPECTRAL-ANALYSIS

被引：25

作者：

KAWAI, M

MAKINO, B

TAGA, T

MIWA, T

YAMAMOTO, T

FURUTA, T

YAMAMURA, H

BUTSUGAN, Y

OGAWA, K

HAYASHI, M

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

[2] ASAHI CHEM IND CO LTD,INST LIFE SCI RES,SHIZUOKA 41023,JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1994年 / 67卷 / 01期

关键词：

D O I：

10.1246/bcsj.67.222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

X-Ray crystallographic analysis of two steroid derivatives, 5 alpha,6 alpha-epoxyphysalin B and 2,3-dihydrophysalin B, have been undertaken, revealing their closely similar crystal structures to each other. Their H-1 NMR spectra, as well as that of the parent compound physalin B, a 13,14-seco-16,24-cyclosteroid from Physalis alkekengi, have been analyzed based on the crystal structures of these derivatives.

引用

页码：222 / 226

页数：5

共 13 条

[1] POTENTIAL ANTI-TUMOR AGENTS .17. PHYSALIN-B AND 25,26-EPIDIHYDROPHYSALIN-C FROM WITHERINGIA-COCCOLOBOIDES [J].

ANTOUN, MD ;

ABRAMSON, D ;

TYSON, RL ;

CHANG, CJ ;

MCLAUGHLIN, JL ;

PECK, G ;

CASSADY, JM .

JOURNAL OF NATURAL PRODUCTS, 1981, 44 (05) :579-585

[2] WITHANOLIDE-Y, A WITHANOLIDE FROM A HYBRID OF WITHANIA-SOMNIFERA [J].

BESSALLE, R ;

LAVIE, D ;

FROLOW, F .

PHYTOCHEMISTRY, 1987, 26 (06) :1797-1800

[3]

Cromer D.T, 1974, INT TABLES XRAY CRYS, VIV

[4]

DEBAERDEMAKER T, 1988, MULTAN88 SYSTEM COMP

[5] STEROIDAL CONSTITUENTS OF PHYSALIS-MINIMA (SOLANACEAE) [J].

GLOTTER, E ;

KIRSON, I ;

ABRAHAM, A ;

SETHI, PD ;

SUBRAMANIAN, SS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (14) :1370-1374

[6] CONTACT ELECTRON-SPIN COUPLING OF NUCLEAR MAGNETIC MOMENTS [J].

KARPLUS, M .

JOURNAL OF CHEMICAL PHYSICS, 1959, 30 (01) :11-15

[7] H-1-NMR SPECTRAL-ANALYSIS OF PHYSALIN-A, A 13,14-SECO-16,24-CYCLOSTEROID, BASED ON CRYSTAL-STRUCTURE OF (25R)-2,3,25,27-TETRAHYDROPHYSALIN-A DIMETHANOL SOLVATE [J].

KAWAI, M ;

TAGA, T ;

MIWA, Y ;

BUTSUGAN, Y .

JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH, 1992, 22 (02) :131-137

[8] PHYSALIN-N AND PHYSALIN-O FROM PHYSALIS-ALKEKENGI [J].

KAWAI, M ;

OGURA, T ;

MAKINO, B ;

MATSUMOTO, A ;

YAMAMURA, H ;

BUTSUGAN, Y ;

HAYASHI, M .

PHYTOCHEMISTRY, 1992, 31 (12) :4299-4302

[9] A NEW PHYSALIN FROM PHYSALIS-ALKEKENGI - STRUCTURE OF PHYSALIN-L [J].

KAWAI, M ;

MATSUURA, T ;

KYUNO, S ;

MATSUKI, H ;

TAKENAKA, M ;

KATSUOKA, T ;

BUTSUGAN, Y ;

SAITO, K .

PHYTOCHEMISTRY, 1987, 26 (12) :3313-3317

[10] ACTIVATED CHARCOAL-MEDIATED HYDROXYLATION UNDER VERY MILD CONDITIONS - CONVERSION OF PHYSALIN-B INTO 25-HYDROXYPHYSALIN-B [J].

MAKINO, B ;

KAWAI, M ;

YAMAMOTO, T ;

YAMAMURA, H ;

BUTSUGAN, Y ;

HAYASHI, M ;

OGAWA, K .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (19) :1430-1431

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