THE SQUALESTATINS - C-3 DECARBOXYLATION STUDIES AND REARRANGEMENT TO THE 6,8-DIOXABICYCLO[3.2.1]OCTANE RING-SYSTEM

被引：16

作者：

CHAN, C

INGLIS, GGA

PROCOPIOU, PA

ROSS, BC

SRIKANTHA, ARP

WATSON, NS

机构：

[1] Department of Medicinal Chemistry, Glaxo Group Research Ltd., Greenford, Middlesex UB6 0HF, Greenford Road

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)61752-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Decarboxy squalestatins 3 and 4 were synthesised via photolysis of t-butyl peroxyester 7. Lactol 10 was isolated unexpectedly from both HCl-dioxan cleavage of 8, a by-product of the photolysis, and attempted Barton decarboxylation of 6. In TFA under anhydrous conditions, 8 was converted to the tricyclic ether 11.

引用

页码：6143 / 6146

页数：4

共 7 条

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