DETECTING CHANGES IN NEURONAL ACTIVITIES INDUCED BY N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE USING NONLINEAR DYNAMICS TECHNIQUES

被引:1
作者
ASZODI, A
CRUNELLI, V
SOLTESZ, I
机构
[1] UNIV OXFORD,DEPT PHARMACOL,MRC,ANAT NEUROPHARMACOL UNIT,OXFORD OX1 3QT,ENGLAND
[2] ST GEORGE HOSP,SCH MED,DEPT PHARMACOL,LONDON SW17 0RE,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/0306-4522(92)90185-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The dynamics of N-methyl-D-aspartate receptor blockade-induced transitions between two types of intracellularly recorded spontaneous membrane potential oscillation from cat thalamic neurons have been studied using non-linear dynamics techniques. We report that, as previously predicted by theoretical studies, the number of degrees of freedom of these oscillations (the minimal number of independent variables governing the activity) is small, i.e. they are low dimensional. The N-methyl-D-aspartate receptor antagonists DL-2-amino-5-phosphono-valcric acid and ketamine, which transformed one type of oscillation into another, decreased the calculated dimension. DL-2-Amino-5-phosphono-valerie acid had no effect on the dimension when Mg2+ was present in the perfusion medium. The decrease in dimension was gradual and its time-course had a sigmoidal shape. It is suggested that the application of the machinery of dynamical systems theory might help to detect and monitor drug-induced membrane potential state transitions and to identify the factors underlying membrane potential oscillations.
引用
收藏
页码:785 / 791
页数:7
相关论文
共 32 条
  • [21] DYNAMICS OF SPONTANEOUS NEURAL ACTIVITY IN THE SIMIAN MOTOR CORTEX - THE DIMENSION OF CHAOTIC NEURONS
    RAPP, PE
    ZIMMERMAN, ID
    ALBANO, AM
    DEGUZMAN, GC
    GREENBAUN, NN
    [J]. PHYSICS LETTERS A, 1985, 110 (06) : 335 - 338
  • [22] Rinzel J, 1989, METHODS NEURONAL MOD
  • [23] A MODEL OF A THALAMIC NEURON
    ROSE, RM
    HINDMARSH, JL
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1985, 225 (1239): : 161 - 193
  • [24] RYAN LJ, 1989, TRENDS NEUROSCI, V12, P494, DOI 10.1016/0166-2236(89)90105-7
  • [25] BRAINS MAKE CHAOS TO MAKE SENSE OF THE WORLD
    SKARDA, CA
    FREEMAN, WJ
    [J]. BEHAVIORAL AND BRAIN SCIENCES, 1987, 10 (02) : 161 - 173
  • [26] 2 INWARD CURRENTS AND THE TRANSFORMATION OF LOW-FREQUENCY OSCILLATIONS OF RAT AND CAT THALAMOCORTICAL CELLS
    SOLTESZ, I
    LIGHTOWLER, S
    LERESCHE, N
    JASSIKGERSCHENFELD, D
    POLLARD, CE
    CRUNELLI, V
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 441 : 175 - 197
  • [27] THE FUNCTIONAL-STATES OF THE THALAMUS AND THE ASSOCIATED NEURONAL INTERPLAY
    STERIADE, M
    LLINAS, RR
    [J]. PHYSIOLOGICAL REVIEWS, 1988, 68 (03) : 649 - 742
  • [28] ABOLITION OF SPINDLE OSCILLATIONS IN THALAMIC NEURONS DISCONNECTED FROM NUCLEUS RETICULARIS THALAMI
    STERIADE, M
    DESCHENES, M
    DOMICH, L
    MULLE, C
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1985, 54 (06) : 1473 - 1497
  • [29] Takens F., 1981, DYNAMICAL SYSTEMS TU, V898, P366, DOI [10.1007/BFb0091924, 10.1007/BFB0091924, 10.1007/bfb0091924, DOI 10.1007/BFB0091924]
  • [30] AN N-METHYLASPARTATE RECEPTOR-MEDIATED SYNAPSE IN RAT CEREBRAL-CORTEX - A SITE OF ACTION OF KETAMINE
    THOMSON, AM
    WEST, DC
    LODGE, D
    [J]. NATURE, 1985, 313 (6002) : 479 - 481