SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-DEACETYLPACLITAXEL

被引：37

作者：

NEIDIGH, KA

GHARPURE, MM

RIMOLDI, JM

KINGSTON, DGI

JIANG, YQ

HAMEL, E

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 37期

关键词：

D O I：

10.1016/0040-4039(94)85018-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Deacetylpaclitaxel, prepared from baccatin III via two synthetic approaches and from paclitaxel via one synthetic approach, has minimal effects on tubulin polymerization and is not cytotoxic to human CA46 Burkitt lymphoma cells.

引用

页码：6839 / 6842

页数：4

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