ASSOCIATION BETWEEN PROTO-ONCOPROTEIN REL AND TATA-BINDING PROTEIN MEDIATES TRANSCRIPTIONAL ACTIVATION BY NF-KAPPA-B

被引：153

作者：

KERR, LD

RANSONE, LJ

WAMSLEY, P

SCHMITT, MJ

BOYER, TG

ZHOU, Q

BERK, AJ

VERMA, IM

机构：

[1] SALK INST BIOL STUDIES,MOLEC BIOL & VIROL LAB,SAN DIEGO,CA 92138

[2] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

来源：

NATURE | 1993年 / 365卷 / 6445期

关键词：

D O I：

10.1038/365412a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappaB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fall to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappaB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

引用

页码：412 / 419

页数：8

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