REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES

被引：74

作者：

HOLMES, EC

NEE, S

RAMBAUT, A

GARNETT, GP

HARVEY, PH

机构：

[1] Wellcome Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1995年 / 349卷 / 1327期

基金：

英国惠康基金;

关键词：

D O I：

10.1098/rstb.1995.0088

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to trace the dynamics of viral transmission within populations. Case studies document the worldwide spread of Human Immunodeficiency Virus type 1 (HIV-1) and hepatitis C virus (HCV). Despite similarities between these viruses, especially in their transmission routes, they are shown to have very different epidemiological histories. A possible reason for the difference is that HCV has coexisted longer with human populations.

引用

页码：33 / 40

页数：8