ON THE ROLE OF VASOACTIVE INTESTINAL POLYPEPTIDE AND TACHYKININS IN THE SECRETORY REFLEX ELICITED BY CHEMICAL PERITONITIS IN THE CAT SMALL-INTESTINE

被引：16

作者：

BRUNSSON, I

FAHRENKRUG, J

JODAL, M

SJOQVIST, A

THEODORSSON, E

LUNDGREN, O

机构：

[1] GOTHENBURG UNIV,DEPT PHYSIOL,BOX 33031,S-40033 GOTHENBURG,SWEDEN

[2] BISPEBJERG HOSP,DEPT CLIN CHEM,DK-2400 COPENHAGEN,DENMARK

[3] KAROLINSKA HOSP,DEPT CLIN CHEM,S-10401 STOCKHOLM 60,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1990年 / 139卷 / 01期

关键词：

Enteric nervous system; Inflammation; Intestinal secretion; Methionine-enkephalin; Tachykinins; Vasoactive intestinal polypeptide;

D O I：

10.1111/j.1748-1716.1990.tb08898.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Peritonitis induced by serosal application of 0.1 M hydrochloric acid causes net fluid secretion via the enteric nervous system. The aim of the present study was to investigate the roles of vasoactive intestinal peptide (VIP) and tachykinins in this reflex(es). The release of tachykinins (substance P [SP], neurokinin A [NKA], neuropeptide K [NPK]) and VIP into the mesenteric circulation, net fluid transport, intestinal blood flow and sometimes motility were recorded simultaneously in extrinsically denervated jejunal segments of the cat in vivo. The release of both VIP and NKA was increased upon application of HCl to the cat jejunal serosa. Tetrodotoxin, hexamethonium and methionine enkephalin inhibited both the induced VIP release and the secretory response. The increased release of NKA was unaffected by hexamethonium. We propose that the intramural secretory reflex evoked by acid application of the serosa consists of an 'afferent' tachykinin neuron, a cholinergic interneuron and an 'efferent' VIPergic neuron innervating the secretory enterocytes.

引用

页码：63 / 75

页数：13

共 51 条

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