ON THE ROLE OF VASOACTIVE INTESTINAL POLYPEPTIDE AND TACHYKININS IN THE SECRETORY REFLEX ELICITED BY CHEMICAL PERITONITIS IN THE CAT SMALL-INTESTINE

被引:16
作者
BRUNSSON, I
FAHRENKRUG, J
JODAL, M
SJOQVIST, A
THEODORSSON, E
LUNDGREN, O
机构
[1] GOTHENBURG UNIV,DEPT PHYSIOL,BOX 33031,S-40033 GOTHENBURG,SWEDEN
[2] BISPEBJERG HOSP,DEPT CLIN CHEM,DK-2400 COPENHAGEN,DENMARK
[3] KAROLINSKA HOSP,DEPT CLIN CHEM,S-10401 STOCKHOLM 60,SWEDEN
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1990年 / 139卷 / 01期
关键词
Enteric nervous system; Inflammation; Intestinal secretion; Methionine-enkephalin; Tachykinins; Vasoactive intestinal polypeptide;
D O I
10.1111/j.1748-1716.1990.tb08898.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Peritonitis induced by serosal application of 0.1 M hydrochloric acid causes net fluid secretion via the enteric nervous system. The aim of the present study was to investigate the roles of vasoactive intestinal peptide (VIP) and tachykinins in this reflex(es). The release of tachykinins (substance P [SP], neurokinin A [NKA], neuropeptide K [NPK]) and VIP into the mesenteric circulation, net fluid transport, intestinal blood flow and sometimes motility were recorded simultaneously in extrinsically denervated jejunal segments of the cat in vivo. The release of both VIP and NKA was increased upon application of HCl to the cat jejunal serosa. Tetrodotoxin, hexamethonium and methionine enkephalin inhibited both the induced VIP release and the secretory response. The increased release of NKA was unaffected by hexamethonium. We propose that the intramural secretory reflex evoked by acid application of the serosa consists of an 'afferent' tachykinin neuron, a cholinergic interneuron and an 'efferent' VIPergic neuron innervating the secretory enterocytes.
引用
收藏
页码:63 / 75
页数:13
相关论文
共 51 条
[41]  
PERNOW B, 1983, PHARMACOL REV, V35, P85
[42]   DISTRIBUTION OF PEPTIDE-CONTAINING AND CATECHOLAMINE-CONTAINING NEURONS IN THE GASTROINTESTINAL-TRACT OF RAT AND GUINEA-PIG - IMMUNOHISTOCHEMICAL STUDIES WITH ANTISERA TO SUBSTANCE-P, VASOACTIVE INTESTINAL POLYPEPTIDE, ENKEPHALINS, SOMATOSTATIN, GASTRIN-CHOLECYSTOKININ, NEUROTENSIN AND DOPAMINE BETA-HYDROXYLASEIC [J].
SCHULTZBERG, M ;
HOKFELT, T ;
NILSSON, G ;
TERENIUS, L ;
REHFELD, JF ;
BROWN, M ;
ELDE, R ;
GOLDSTEIN, M ;
SAID, S .
NEUROSCIENCE, 1980, 5 (04) :689-744
[43]   VASOACTIVE INTESTINAL PEPTIDE STIMULATION OF ADENYLATE CYCLASE AND ACTIVE ELECTROLYTE SECRETION IN INTESTINAL-MUCOSA [J].
SCHWARTZ, CJ ;
KIMBERG, DV ;
SHEERIN, HE ;
FIELD, M ;
SAID, SI .
JOURNAL OF CLINICAL INVESTIGATION, 1974, 54 (03) :536-544
[44]  
SIEGEL S, 1956, NONPARAMETRICAL STAT
[45]   THE EFFECT ON INTESTINAL FLUID TRANSPORT OF EXPOSING THE SEROSA TO HYDROCHLORIC-ACID - A STUDY OF MECHANISMS [J].
SJOQVIST, A ;
CASSUTO, J ;
JODAL, M ;
BRUNSSON, I ;
LUNDGREN, O .
ACTA PHYSIOLOGICA SCANDINAVICA, 1982, 116 (04) :447-454
[46]   FURTHER EVIDENCE FOR A GLUCOSE-ACTIVATED SECRETORY MECHANISM IN THE JEJUNUM OF THE CAT [J].
SJOVALL, H ;
JODAL, M ;
LUNDGREN, O .
ACTA PHYSIOLOGICA SCANDINAVICA, 1984, 120 (03) :437-443
[47]   THE EFFECT OF VAGAL NERVE-STIMULATION ON NET FLUID TRANSPORT IN THE SMALL-INTESTINE OF THE CAT [J].
SJOVALL, H ;
BRUNSSON, I ;
JODAL, M ;
LUNDGREN, O .
ACTA PHYSIOLOGICA SCANDINAVICA, 1983, 117 (03) :351-357
[48]   NEUROPEPTIDE-K - A MAJOR TACHYKININ IN PLASMA AND TUMOR-TISSUES FROM CARCINOID PATIENTS [J].
THEODORSSONNORHEIM, E ;
NORHEIM, I ;
OBERG, K ;
BRODIN, E ;
LUNDBERG, JM ;
TATEMOTO, K ;
LINDGREN, PG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 131 (01) :77-83
[49]  
TURNBERG LA, 1984, FALK S, V36, P417
[50]  
WALLING MW, 1977, GASTROENTEROLOGY, V73, P89