HPLC SEPARATIONS OF NORMAL AND MODIFIED NUCLEOBASES AND NUCLEOSIDES ON AN AMINO SILICA-GEL COLUMN

被引：25

作者：

RAVANAT, JL ^{[1
]}

DOUKI, T ^{[1
]}

INCARDONA, MF ^{[1
]}

CADET, J ^{[1
]}

机构：

[1] CEN,SESAM,DRFMC,LES ACIDES NUCL LAB,BP 85X,F-38041 GRENOBLE,FRANCE

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 15期

关键词：

D O I：

10.1080/10826079308019642

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An amino substituted silica gel column was used for the normal phase HPLC separation of nucleic acid components, including free bases and the corresponding 2'-deoxyribo- and ribonucleosides. The chromatographic system was also found to be particularly convenient for the separation of various modified nucleosides, including oxidation products of 2'-deoxyguanosine and pyrimidine components, thymidine cyclobutane dimers, dinucleoside monophosphate photoproducts and pyrimidine (6-4) pyrimidone adducts.

引用

页码：3185 / 3202

页数：18

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