IMMUNIZATION OF SHEEP AGAINST HEARTWATER WITH INACTIVATED COWDRIA-RUMINANTIUM

被引：59

作者：

MAHAN, SM ^{[1
]}

ANDREW, HR ^{[1
]}

TEBELE, N ^{[1
]}

BURRIDGE, MJ ^{[1
]}

BARBET, AF ^{[1
]}

机构：

[1] UNIV FLORIDA,COLL VET MED,DEPT INFECT DIS,GAINESVILLE,FL 32611

来源：

RESEARCH IN VETERINARY SCIENCE | 1995年 / 58卷 / 01期

关键词：

D O I：

10.1016/0034-5288(95)90087-X

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The immunisation of sheep with inactivated Cowdria ruminantium organisms (the causative agent of heartwater) emulsified in Freund's adjuvant induced protective immunity against a homologous challenge with virulent cell culture-derived C ruminantium organisms. This protective immunity was associated with the development of high titres of C ruminantium-specific antibodies, a low level of rickettsiosis in brain endothelium and no mortalities. In contrast, when unimmunised sheep were challenged, they developed higher levels of rickettsiosis in brain endothelium, and some of them died. This method of immunisation against heart-water has the potential to replace the infection and treatment method that is in current use.

引用

页码：46 / 49

页数：4

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