MULTIPLE GROWTH-FACTOR MESSENGER-RNAS ARE EXPRESSED IN CHICKEN ADIPOCYTE PRECURSOR CELLS

被引:17
作者
BURT, DW
BOSWELL, JM
PATON, IR
BUTTERWITH, SC
机构
[1] Department of Cellular, Molecular Biology AFRC Inst. of Animal Physiology and Genetics Research Edinburgh Research Station R
关键词
D O I
10.1016/0006-291X(92)90444-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have examined the expression of growth factor genes in primary cultures of chicken adipocyte precursors. RNA was extracted from proliferating and differentiated cells, reversed transcribed and amplified by PCR using gene specific primers. The identity of the PCR products was confirmed by restriction mapping. We show, for the first time, constitutive expression of TGF-β2, TGF-β3, TGF-β4 and bFGF genes in chicken adipocyte precursors. We also detect GH-independant, but differentiation-dependant IGF-I gene expression. The synthesis and action of these growth factors supports the hypothesis that they act as autocrine and/or paracrine regulators of adipocyte precursor cell proliferation and differentiation. © 1992.
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收藏
页码:1298 / 1305
页数:8
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