DRUG-RESISTANT TUBERCULOSIS IN THE 1990S

被引:50
作者
YEW, WW
CHAU, CH
机构
[1] Tuberculosis and Chest Unit, Grantham Hospital, Aberdeen
关键词
DRUG-RESISTANT TUBERCULOSIS; EPIDEMIOLOGY AND MECHANISMS; RAPID DIAGNOSIS; TREATMENT MODALITIES;
D O I
10.1183/09031936.95.08071184
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
There has been an upsurge of tuberculosis in many parts of the world in the past decade, The high rates of drug-resistant tuberculosis currently reported in many countries are alarming, The most catastrophic phenomenon is the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. These organisms have caused epidemic outbreaks in nosocomial and healthcare settings in the USA and some European countries. In addition to immigration, poverty, alcoholism and intravenous substance abuse, human immunodeficiency virus (HIV) infection has also had a significant impact on the prevalence of drug resistance, since amongst these patient groups a common factor giving rise to drug resistance is noncompliance. Rapid drug susceptibility tests are needed, and effective chemotherapy regimens with newly developed drugs in combination with traditional second-line antituberculosis agents for established multidrug-resistant tuberculosis me urgently being sought. There is also a quest for other novel modalities of therapy, Measures should be actively adopted to prevent the development of drug resistance. Well formulated short-course chemotherapy as initial treatment and ensurance of compliance are the most important components, The organization of a national tuberculosis control programme with a sound and adequately functioning infrastructure remains the most effective strategy to combat the resurgence of tuberculosis and to curtail drug resistance.
引用
收藏
页码:1184 / 1192
页数:9
相关论文
共 101 条
  • [21] AN OUTBREAK OF TUBERCULOSIS CAUSED BY MULTIPLE-DRUG-RESISTANT TUBERCLE-BACILLI AMONG PATIENTS WITH HIV-INFECTION
    FISCHL, MA
    UTTAMCHANDANI, RB
    DAIKOS, GL
    POBLETE, RB
    MORENO, JN
    REYES, RR
    BOOTA, AM
    THOMPSON, LM
    CLEARY, TJ
    LAI, SH
    [J]. ANNALS OF INTERNAL MEDICINE, 1992, 117 (03) : 177 - 183
  • [22] Fox W., 1990, Indian Journal of Tuberculosis, V37, P175
  • [23] DRUG-COMBINATIONS AND THE BIOAVAILABILITY OF RIFAMPICIN
    FOX, W
    [J]. TUBERCLE, 1990, 71 (04): : 241 - 245
  • [24] THE EMERGENCE OF DRUG-RESISTANT TUBERCULOSIS IN NEW-YORK-CITY
    FRIEDEN, TR
    STERLING, T
    PABLOSMENDEZ, A
    KILBURN, JO
    CAUTHEN, GM
    DOOLEY, SW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (08) : 521 - 526
  • [25] DRUG-RESISTANCE IN TUBERCULOSIS - ITS NOT ALWAYS THE PATIENTS FAULT
    GANGADHARAM, PRJ
    [J]. TUBERCLE AND LUNG DISEASE, 1993, 74 (01): : 65 - 67
  • [26] THE SERUM RIFABUTIN CONCENTRATIONS IN A PATIENT SUCCESSFULLY TREATED FOR MULTIRESISTANT MYCOBACTERIUM-TUBERCULOSIS INFECTION
    GILLESPIE, SH
    BASKERVILLE, AJ
    DAVIDSON, RN
    FELMINGHAM, D
    BRYCESON, ADM
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 (03) : 490 - 491
  • [27] GILLESPIE SH, 1992, CIPROFLOXACIN PULMON, V2, P27
  • [28] TREATMENT OF 171 PATIENTS WITH PULMONARY TUBERCULOSIS RESISTANT TO ISONIAZID AND RIFAMPIN
    GOBLE, M
    ISEMAN, MD
    MADSEN, LA
    WAITE, D
    ACKERSON, L
    HORSBURGH, CR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (08) : 527 - 532
  • [29] DNA FINGERPRINTS OF MYCOBACTERIUM-TUBERCULOSIS DO NOT CHANGE DURING THE DEVELOPMENT OF RIFAMPICIN RESISTANCE
    GODFREYFAUSSETT, P
    STOKER, NG
    SCOTT, JAG
    PASVOL, G
    KELLY, P
    CLANCY, L
    [J]. TUBERCLE AND LUNG DISEASE, 1993, 74 (04): : 240 - 243
  • [30] GOOD RC, 1989, CLIN CHEST MED, V10, P315