THE ROLE OF NATURAL-KILLER-CELLS IN IMMUNE SURVEILLANCE OF CANCER

被引：246

作者：

WHITESIDE, TL ^{[1
]}

HERBERMAN, RB ^{[1
]}

机构：

[1] UNIV PITTSBURGH,SCH MED,PITTSBURGH,PA 15213

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期

关键词：

D O I：

10.1016/0952-7915(95)80080-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past year, a subset of natural killer cells designated 'A-NK cells' has been characterized. These immune cells appear to be able to enter solid tissues, migrate to sites of metastasis and eliminate malignant tissue cells, but spare normal tissue cells. They appear to be ideal surveillance cells, readily capable of upregulating antitumor functions in response to local activation signals.

引用

收藏

页码：704 / 710

页数：7

相关论文

共 57 条

[41] PROSPECTIVE RANDOMIZED TRIAL OF HIGH-DOSE INTERLEUKIN-2 ALONE OR IN CONJUNCTION WITH LYMPHOKINE-ACTIVATED KILLER-CELLS FOR THE TREATMENT OF PATIENTS WITH ADVANCED CANCER [J].

ROSENBERG, SA ;

LOTZE, MT ;

YANG, JC ;

TOPALIAN, SL ;

CHANG, AE ;

SCHWARTZENTRUBER, DJ ;

AEBERSOLD, P ;

LEITMAN, S ;

LINEHAN, WM ;

SEIPP, CA ;

WHITE, DE ;

STEINBERG, SM .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (08) :622-632

[42]

SONDEL PM, 1989, IL2 ACTIVATED KILLER, P1

[43] MECHANISMS OF APOPTOSIS - INTEGRATION OF GENETIC, BIOCHEMICAL, AND CELLULAR INDICATORS [J].

STEWART, BW .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (17) :1286-1296

[44] CHARACTERISTICS OF NATURAL-KILLER CELLS IN THE MURINE INTESTINAL EPITHELIUM AND LAMINA PROPRIA [J].

TAGLIABUE, A ;

BEFUS, AD ;

CLARK, DA ;

BIENENSTOCK, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (06) :1785-1796

[45]

VITOLO D, 1993, J IMMUNOL, V151, P1926

[46]

VUJANOVIC NL, 1995, J IMMUNOL, V154, P6324

[47]

VUJANOVIC NL, 1995, J IMMUNOL, V154, P281

[48] DISTINCT PHENOTYPIC AND FUNCTIONAL-CHARACTERISTICS OF HUMAN NATURAL-KILLER-CELLS OBTAINED BY RAPID INTERLEUKIN 2-INDUCED ADHERENCE TO PLASTIC [J].

VUJANOVIC, NL ;

RABINOWICH, H ;

LEE, YJ ;

JOST, L ;

HERBERMAN, RB ;

WHITESIDE, TL .

CELLULAR IMMUNOLOGY, 1993, 151 (01) :133-157

[49]

VUJANOVIC NL, 1994, TUMOR IMMUNOLOGY BAS, V4, P41

[50] HUMAN NATURAL-KILLER-CELLS IN HEALTH AND DISEASE [J].

WHITESIDE, TL ;

HERBERMAN, RB .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1994, 1 (02) :125-133

← 1 2 3 4 5 6 →