IDENTIFICATION, NUCLEAR-LOCALIZATION, AND DNA-BINDING ACTIVITY OF THE ZINC FINGER PROTEIN ENCODED BY THE EVI-1 MYELOID TRANSFORMING GENE

被引：77

作者：

MATSUGI, T

MORISHITA, K

IHLE, JN

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT BIOCHEM, 332 N LAUDERDALE, MEMPHIS, TN 38105 USA

[2] UNIV TENNESSEE, CTR HLTH SCI, DEPT BIOCHEM, MEMPHIS, TN 38163 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 03期

关键词：

D O I：

10.1128/MCB.10.3.1259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of the Evi-1 zinc finger gene is a common event associated with transformation of murine myeloid leukemias. To characterize the gene product, we developed antisera against various protein domains. These antisera primarily detected a 145-kilodalton nuclear protein that bound double-stranded DNA. Binding was inhibited by chelating agents and partially restored by zinc ions.

引用

页码：1259 / 1264

页数：6

共 24 条

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