TRANSDERMAL LONTOPHORETIC PEPTIDE DELIVERY - INVITRO AND INVIVO STUDIES WITH LUTEINIZING-HORMONE-RELEASING HORMONE

被引:44
作者
HEIT, MC
WILLIAMS, PL
JAYES, FL
CHANG, SK
RIVIERE, JE
机构
[1] N CAROLINA STATE UNIV, CTR CUTANEOUS PHARMACOL & TOXICOL, RALEIGH, NC 27606 USA
[2] N CAROLINA STATE UNIV, DEPT ANIM SCI, RALEIGH, NC 27606 USA
关键词
D O I
10.1002/jps.2600820304
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Protein and peptide drugs are not orally active. Their large molecular size and charged character make them poor candidates for passive transdermal delivery. With an applied electromotive force, these drugs can be forced through the skin to be absorbed by the systemic circulation. The present study investigates the transdermal iontophoretic delivery of a peptide hormone in an in vitro model system, the isolated perfused porcine skin flap, as well as in vivo. It is shown that with knowledge of the systemic disposition of the drug, transdermal fluxes can be utilized to accurately predict in vivo serum concentrations. It is also shown that the iontophoretically delivered hormone retains both its immunologic and biologic activity.
引用
收藏
页码:240 / 243
页数:4
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