OXIDATIVE INTRAMOLECULAR [4+2]CYCLOADDITION OF SILYLENE-PROTECTED 2-PYRIDONE DERIVATIVES - A SHORT AND EFFICIENT SYNTHESIS OF THE DEF-RING OF FREDERICAMYCIN-A

被引：13

作者：

KITA, Y

UENO, H

KITAGAKI, S

KOBAYASHI, K

LIO, K

AKAI, S

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 06期

关键词：

D O I：

10.1039/c39940000701

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermal treatment of 2-pyridone derivatives 2 with dimethyldichlorosilane, triethylamine and chloranil in benzene gives 8-hydroxyisoquinolones 4 in high yields by oxidative intramolecular [4 + 2]cycloaddition which are used in the synthesis of the fully functionalized DEF-ring 14 of fredericamycin A.

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页码：701 / 702

页数：2

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