LOSS OF FUNCTION MUTATION IN THE YEAST MULTIPLE-DRUG RESISTANCE GENE PDR5 CAUSES A REDUCTION IN CHLORAMPHENICOL EFFLUX

被引：39

作者：

LEONARD, PJ

RATHOD, PK

GOLIN, J

机构：

[1] CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064

[2] ALLENTOWN COLL,DEPT BIOL,CENTER VALLEY,PA 18034

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 10期

关键词：

D O I：

10.1128/AAC.38.10.2492

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The yeast (Saccharomyces cerevisiae) PDRS gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDRS result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDRS (wild-type) control.

引用

页码：2492 / 2494

页数：3

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