SELF-REPLICATING MOLECULES - A 2ND GENERATION

被引：68

作者：

WINTNER, EA ^{[1
]}

CONN, MM ^{[1
]}

REBEK, J ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 20期

关键词：

D O I：

10.1021/ja00099a003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of self-complementary structures in replication experiments is discussed, and a second generation of self-replicating molecules is introduced. Key design elements of the new system are described, specifically a high affinity (K-a similar to 10(5) M(-1) in CDCl3) between the two complementary reactive components and the careful placement of nucleophilic and electrophilic centers within the system. These considerations preclude intramolecular reactions within two-component complexes, thus minimizing undesirable background reactions. Autocatalysis is observed in the new systems, and by using appropriate control experiments the autocatalysis is traced to template effects.

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收藏

页码：8877 / 8884

页数：8

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