THE NMDA RECEPTOR ANTAGONIST MK-801 PREVENTS IMIPRAMINE-INDUCED SUPERSENSITIVITY TO QUINPIROLE

被引：18

作者：

DAQUILA, PS ^{[1
]}

SIAS, A ^{[1
]}

GESSA, GL ^{[1
]}

SERRA, G ^{[1
]}

机构：

[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 224卷 / 2-3期

关键词：

IMIPRAMINE (CHRONIC); NMDA RECEPTORS; DOPAMINE RECEPTORS; SUPERSENSITIVITY;

D O I：

10.1016/0014-2999(92)90805-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic treatment with imipramine enhanced the locomotor stimulant response to quinpirole (0.3 mg/kg s.c.), a dopamine D2/D3 receptor agonist. Chronic, but not acute, blockade of the NMDA receptor with the non-competitive antagonist MK-801 (0.3 mg/kg i.p.) prevented the imipramine-induced potentiation of the quinpirole effect. The results suggest that NMDA receptors play a role in the development of supersensitivity to dopamine receptor agonists produced by chronic antidepressant treatment.

引用

页码：199 / 202

页数：4

共 16 条

[1] INVIVO MODULATION OF EXCITATORY AMINO-ACID RECEPTORS - MICRODIALYSIS STUDIES ON N-METHYL-D-ASPARTATE-EVOKED STRIATAL DOPAMINE RELEASE AND EFFECTS OF ANTAGONISTS
CARROZZA, DP
FERRARO, TN
GOLDEN, GT
REYES, PF
HARE, TA
[J]. BRAIN RESEARCH, 1992, 574 (1-2) : 42 - 48
[2] EFFECT OF CHRONIC TREATMENT WITH DIZOCILPINE (MK-801) ON THE BEHAVIORAL-RESPONSE TO DOPAMINE RECEPTOR AGONISTS IN THE RAT
DALLOLIO, R
GANDOLFI, O
MONTANARO, N
[J]. PSYCHOPHARMACOLOGY, 1992, 107 (04) : 591 - 594
[3] SELECTIVE ADENYLATE-CYCLASE INCREASE IN THE LIMBIC AREA OF LONG-TERM IMIPRAMINE-TREATED RATS
DEMONTIS, GM
DEVOTO, P
GESSA, GL
PORCELLA, A
SERRA, G
TAGLIAMONTE, A
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 180 (01) : 169 - 174
[4] NMDA RECEPTORS AND INVIVO DOPAMINE RELEASE IN THE NUCLEUS-ACCUMBENS AND NUCLEUS-CAUDATUS
IMPERATO, A
SCROCCO, MG
BACCHI, S
ANGELUCCI, L
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (03) : 555 - 556
[5] EFFECT OF MK-801 ON ENDOGENOUS DOPAMINE RELEASE INVIVO
KASHIHARA, K
HAMAMURA, T
OKUMURA, K
OTSUKI, S
[J]. BRAIN RESEARCH, 1990, 528 (01) : 80 - 82
[6] THE EFFECT OF PHENCYCLIDINE AND DL-2-AMINO-5-PHOSPHONOVALERIC ACID ON N-METHYL-D-ASPARTIC ACID-INDUCED CHANGES IN EXTRACELLULAR CONCENTRATION OF DOPAMINE AND DOPAC IN THE RAT NEOSTRIATUM
MAREK, P
CHAPMAN, CD
HOWARD, S
[J]. NEUROPHARMACOLOGY, 1992, 31 (02) : 123 - 127
[7] PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF EXCITATORY AMINO-ACIDS DURING CENTRAL-NERVOUS-SYSTEM DEVELOPMENT
MCDONALD, JW
JOHNSTON, MV
[J]. BRAIN RESEARCH REVIEWS, 1990, 15 (01) : 41 - 70
[8] CHRONIC DESIPRAMINE ENHANCES AMPHETAMINE-INDUCED INCREASES IN INTERSTITIAL CONCENTRATIONS OF DOPAMINE IN THE NUCLEUS-ACCUMBENS
NOMIKOS, GG
DAMSMA, G
WENKSTERN, D
FIBIGER, HC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 195 (01) : 63 - 73
[9] ELECTROPHYSIOLOGICAL EVIDENCE THAT INTRASTRIATALLY ADMINISTERED N-METHYL-D-ASPARTATE AUGMENTS STRIATAL DOPAMINE TONE IN THE RAT
OVERTON, P
CLARK, D
[J]. JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1992, 4 (01) : 1 - 14
[10] NUCLEUS-ACCUMBENS NMDA ANTAGONIST DECREASES LOCOMOTOR-ACTIVITY PRODUCED BY COCAINE, HEROIN OR ACCUMBENS DOPAMINE, BUT NOT CAFFEINE
PULVIRENTI, L
SWERDLOW, NR
KOOB, GF
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 40 (04) : 841 - 845

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