STRESSED RATS FAIL TO EXPAND THE CD45RC(+)CD4(+) (TH1-LIKE) T-CELL SUBSET IN RESPONSE TO KLH - POSSIBLE INVOLVEMENT OF IFN-GAMMA

被引：36

作者：

FLESHNER, M ^{[1
]}

HERMANN, J ^{[1
]}

LOCKWOOD, LL ^{[1
]}

LAUDENSLAGER, ML ^{[1
]}

WATKINS, LR ^{[1
]}

MAIER, SF ^{[1
]}

机构：

[1] UNIV COLORADO, HLTH SCI CTR, DEPT PSYCHIAT, BOULDER, CO 80309 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1995年 / 9卷 / 02期

关键词：

D O I：

10.1006/brbi.1995.1011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exposure to stressors effects various aspects of immune function, including the in vivo antibody response. We have previously reported that rats exposed to an acute session of inescapable tail shock (IS) show long-term reductions in anti-KLH (keyhole limpet hemocyanin) IgM and IgG. The mechanisms responsible for this suppression are currently unknown. Previous work has suggested changes in CD4(+) T cells could be important. We report here that exposure to IS results in a reduction in Con A-stimulated IFN-gamma levels in mesenteric lymphocytes and splenocytes taken immediately after IS termination. In addition, IS exposure prevents the KLH-induced increase in the number of CD45RC(+)CD4(+) T cells (Thl-like) in both the mesenteric lymph nodes and the spleen 4 days after immunization. The failure of KLH to expand the CD45RC(+)CD4(+) subset could be due to the stress-induced reduction in LFN-gamma levels reported in cells taken at the time of immunization. Implications of these findings as a mechanism for the decrease in the in vivo antibody response previously reported is discussed. (C) 1995 Academic Press, inc.

引用

页码：101 / 112

页数：12

共 39 条

[21]

McKnight A.J., Barclay A.N., Mason D.W., Molecular cloning of rat interleukin 4 c DNA and analysis of the cytokine repertoire of subsets of CD4+ T cells, Eur. J. Immunol., 21, pp. 1187-1194, (1991)

[22]

Mosmann T., Coffman R.L., Two types of mouse helper T cell clones. Implications for immune regulations, Immunol. Today, 8, pp. 223-227, (1987)

[23]

Moynihan J.A., Ader R., Grota L.J., Schachtman T.R., Cohen N., The effects of stress on the development of immunological memory following low-dose antigen priming ii mice, Brain, Behav. Immun., 4, pp. 1-12, (1990)

[24]

Moynihan J.A., Karp J.D., Cohen N., Cocke R., Alterations in int’rleukin-4 and antibody production following pheromone exposure: Role of glucocorticoids, J. Neuroimmunol., 54, pp. 51-58, (1994)

[25]

Papp I., Wieder K.J., Sablinski T., O'Connell P.J., Milford D.L., Strom T.B., Kupiec-weglinski J.W., Evidence for functional heterogeneity of rat CD4+ T cells in vivo: Differential expression of IL-2 and IL-4 m RNA in recipients of cardiac allografts, J. Immunol., 148, pp. 1308-1314, (1992)

[26]

Peleman R., Wu J.H., Fargeas C., Delespesse G., Recombinant interleukin 4 suppresses the production of interferon γ by human mononuclear cells, J. Exp. Med., 170, pp. 751-1756, (1989)

[27]

Powrie F., Mason D., Phenotypic and functional heterogenity of CD-- T cells, Immunol. Today, 9, pp. 274-277, (1988)

[28]

Powrie F., Mason D., OX-22high CD4+ T cells induced wasting disease with multiple organ pathology: Prevention by the OX22low subset, J. Exp. Med., 172, pp. 1701-1708, (1990)

[29]

Powrie F., Mason D., Subsets of rat CD4+ T ceils defined by their differential expression of variants of the CD45 antigen: Developmental relationships and in vitro and in vivo functions, Curr. Top. Microbiol. Immunol., 159, pp. 79-96, (1990)

[30]

Sarawar S.R., Sparshott S.M., Sutton P., Yang C., Hutchinson I.V., Bell E.B., Rapid reexpression of CD45RC on rat CD4 T cells in vitro correlates with a change in function., 23, pp. 103-107, (1993)

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