PALLADIUM-CATALYZED ENE-TYPE CYCLIZATIONS OF TERPENOID 1,6-ENYNES

被引：8

作者：

KNIERZINGER, A

GRIEDER, A

SCHONHOLZER, P

机构：

[1] Zentrale Forschungseinheiten, F. Hoffmann‐La Roche AG, Basel

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 03期

关键词：

D O I：

10.1002/hlca.19910740308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed ene-type cyclizations of 1,6-enynes 2 yield methylidene-cyclopentane derivatives 3. Removal of protecting groups from 3 furnishes the diols 4 and 5, whose configurations were established by a combination of X-ray and H-1-NMR techniques. The predominant formation of isomers 4 is discussed in the context of two alternative hypothetical mechanisms previously proposed for this type of cyclization.

引用

页码：517 / 530

页数：14

共 23 条

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