REGULATION OF TOPOISOMERASE-II BY MURINE MASTOCYTOMA-CELLS

被引：2

作者：

COLLETT, AG ^{[1
]}

RALPH, RK ^{[1
]}

机构：

[1] UNIV AUCKLAND, DEPT CELLULAR & MOLEC BIOL, PRIVATE BAG 92019, AUCKLAND, NEW ZEALAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1132卷 / 03期

关键词：

TOPOISOMERASE-II; GROWTH; CYTOPLASMIC FACTOR; (MOUSE);

D O I：

10.1016/0167-4781(92)90159-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclei from K21 murine mastocytoma cells do not form topoisomerase II-DNA adducts in response to amsacrine in the absence of a cytoplasmic factor tentatively identified as a type of casein kinase (Darkin, S.J. and Ralph, R.K. (1991) Biochim. Biophys. Acta 1088, 285-291). The stimulatory activity was present in extracts from cells grown in horse serum but not in calf serum. Activity was lost following growth arrest by serum deprivation. In contrast, topoisomerase II activity in isolated nuclei did not decline during growth arrest. These results suggest that the resistance of some non-cycling tumour cells to anti-cancer drugs may result from decreased activation of topoisomerase II.

引用

页码：259 / 264

页数：6

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