OPTICAL RESOLUTION DRUGS BY CAPILLARY ELECTROPHORETIC TECHNIQUES

This review surveys the optical resolution of drugs by capillary electrophoretic (CE) techniques. The CE techniques involve capillary zone electrophoresis, electrokinetic chromatography, capillary gel electrophoresis, capillary isotachophoresis and electrochromatography. Each section is arranged according to species of chiral selectors used in CE from the viewpoint of practical use. Optical resolution of enantiomers by CE techniques is mainly achieved through the modification of the separation solution with chiral additives such as cyclodextrins or proteins. A brief separation theory or separation procedure for each CE technique and some typical applications are also described for practical guidelines.