THE HSP60 PROTEIN OF HELICOBACTER-PYLORI - STRUCTURE AND IMMUNE-RESPONSE IN PATIENTS WITH GASTRODUODENAL DISEASES

被引：112

作者：

MACCHIA, G ^{[1
]}

MASSONE, A ^{[1
]}

BURRONI, D ^{[1
]}

COVACCI, A ^{[1
]}

CENSINI, S ^{[1
]}

RAPPUOLI, R ^{[1
]}

机构：

[1] IMMUNOBIOL RES INST SIENA, VIA FIORENTINA 1, I-53100 SIENA, ITALY

来源：

MOLECULAR MICROBIOLOGY | 1993年 / 9卷 / 03期

关键词：

D O I：

10.1111/j.1365-2958.1993.tb01724.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori is a human pathogen that has been associated with gastritis, peptic ulcer and gastric carcinoma. The role of the direct action of H. pylori virulence factors and of the induction of autoreactive immunity in the development of chronic gastritis has not been clarified yet. Here we report the cloning and molecular characterization of a gene of H. pylori coding for a protein of 58 kDa, recognized by sera of patients affected by H. pylori-induced gastroduodenal diseases. This antigen is present in all the H. pylori strains tested, and it belongs to the Hsp60 family of heat-shock proteins, with high homology with other bacterial and eukaryotic proteins of the same family. This class of homologous proteins has been implicated in the induction of autoimmune disorders in different systems. The presence in infected patients of anti-H. pylori Hsp60 antibodies, potentially cross-reacting with the human homologue, and cross-reactivity between human Hsp60 and a rabbit antiserum against H. pylori Hsp60 suggest that a role of this protein in gastroduodenal diseases is possible.

引用

页码：645 / 652

页数：8

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